翻訳と辞書 Words near each other ・ Epithelantha bokei ・ Epithelantha micromeris ・ Epithele ・ Epithelial basement membrane dystrophy ・ Epithelial cell adhesion molecule ・ Epithelial cell rests of Malassez ・ Epithelial dysplasia ・ Epithelial polarity ・ Epithelial reticular cell ・ Epithelial root sheath ・ Epithelial Simple ciliated ・ Epithelial sodium channel ・ Epithelial sodium channel blocker ・ Epithelial-myoepithelial carcinoma ・ Epithelial-myoepithelial carcinoma of the lung ・ Epithelial–mesenchymal transition ・ Epithelioid ・ Epithelioid cell ・ Epithelioid cell histiocytoma ・ Epithelioid hemangioendothelioma ・ Epithelioid sarcoma ・ Epithelioma ・ Epithelioma cuniculatum ・ Epithelium ・ Epithelopsis ・ Epitherapis ・ Epitheria ・ Epitherina ・ Epithet ・ Epithets in Homer Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Epithelial–mesenchymal transition ： ウィキペディア英語版 Epithelial–mesenchymal transition The epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types. EMT is essential for numerous developmental processes including mesoderm formation and neural tube formation. EMT has also been shown to occur in wound healing, in organ fibrosis and in the initiation of metastasis for cancer progression. ==Introduction== The epithelial-mesenchymal transition was first recognized as a feature of embryogenesis. EMT, and its reverse process, MET (mesenchymal-epithelial transition) are critical for development of many tissues and organs in the developing embryo, and numerous embryonic events such as gastrulation, neural crest formation, heart valve formation, palatogenesis and myogenesis. Epithelial and mesenchymal cells differ in phenotype as well as function. Epithelial cells are closely connected to each other by tight junctions, gap junctions and adherens junctions, have an apico-basal polarity, polarization of the actin cytoskeleton and are bound by a basal lamina at their basal surface. Mesenchymal cells, on the other hand, lack this polarization, have a spindle-shaped morphology and interact with each other only through focal points. Epithelial cells express high levels of E-cadherin, whereas mesenchymal cells express those of N-cadherin, fibronectin and vimentin. Thus, EMT entails profound morphological and phenotypic changes to a cell. Based on the biological context, EMT has been categorized into 3 types - developmental (Type I), fibrosis and wound healing (Type II), and cancer (Type III). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Epithelial–mesenchymal transition」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.